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It is a type I transmembrane protein

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canada goose uk shop TIGIT (T cell immunoglobulin and ITIM domain protein, also known as Vsig9, Vstm3, or WUCAM) is an inhibitory receptor shared by T cells and NK cells containing Ig and ITIM domains. It is a type I transmembrane protein, including the extracellular domain of IgV and immunoglobulin tyrosine acid tail like phosphorylated fragment. TIGIT and CD226 (DNAM 1) compete for binding to ligands CD155 (PVR, NECL5) and CD113 (PVRL3, nectin 3). canada goose uk shop

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